PVRIG(CD112R) Effector Reporter Cell
CBP74120
| I. Background | |
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PVRIG（CD112R），是脊髓灰質(zhì)炎病毒受體(PVR)家族的共抑制受體，在自然殺傷細(xì) 胞（NK）和 T 細(xì)胞上表達(dá)。它與其配體（CD112 或 PVRL2/nectin-2）結(jié)合，抑制 T 細(xì)胞和 NK 細(xì)胞對(duì)癌癥的反應(yīng)。因此，CD112R 作為一種新的免疫檢查點(diǎn)抑制劑在癌癥免疫治療中 具有很高的潛力。 |
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| II. Description | |
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PVRIG(CD112R) Effector Reporter Cell 報(bào)告基因藥靶模型很好的模擬了體內(nèi) PVRIG 的 信號(hào)轉(zhuǎn)導(dǎo)過程，原理見下圖所示。
 Figure 1. PVRIG(CD112R) Effector Reporter Cell |
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| III. Introduction | |
| Expressed gene: |
PVRIG(CD112R) |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | Poliovirus Receptor-related Immunoglobulin Domain-containing Protein, Transmembrane Protein PVRIG, 79270-1, 79270-2 |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
RPMI-1640+10%FBS+1 μg/ml Puromycin+800 μg/ml Hygromycin B
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| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| IV. Representative Data | |
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Figure 3. Dose Response of PVRIG Blocking Antibody in PVRIG(CD112R) Effector Reporter Cell (C7) With CD112 TCR Activator CHO (C1) |
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