Claudin18.2/PANC-1
CBP74143
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產(chǎn)品描述
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| I. Background | |
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Claudin18是位于細(xì)胞膜表面緊密連接的主要成分，它在維持細(xì)胞極性和屏障功能以及促進(jìn)耐酸能力方面起著重要作用。CLDN18的第一個(gè)外顯子可以選擇性剪接，形成兩個(gè)具有高度同源氨基酸序列的不同剪接突變體(CLDN18.1和CLDN18.2)。跨膜蛋白CLDN18由兩個(gè)細(xì)胞外環(huán)、四個(gè)跨膜結(jié)構(gòu)域和一個(gè)細(xì)胞質(zhì)結(jié)構(gòu)域組成。 |
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II. Introduction |
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| Host Cell: | PANC-1 |
| Expressed gene: | Claudin18.2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| III. Description of Host Cell Line | |
| Species: | Human |
| Disease: | A human pancreatic Beta cell: PANC-1 hybrid cell line. Insulin-secreting cell line. |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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1. Claudin18.2/PANC-1 |
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